Abstract #1651

White matter connectome alterations in tuberous sclerosis complex patients with neuropsychiatric disorders revealed by DTI

Jheng-Yan Li¹, Jeng-Dau Tsai^2,3, Chao-Yu Shen^4,5, and Jun-Cheng Weng^1,6,7

¹Department of Medical Imaging and Radiological Sciences, and Bachelor Program in Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ²School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ³Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan, ⁴Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ⁵Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, ⁶Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ⁷Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan

Previous studies indicate that the occurrence of tuberous sclerosis will cause neurotransmission in brain blocked by tumors and produce abnormal discharges. In the study we used diffusion tensor imaging (DTI), graph theoretical analysis (GTA) and network-based statistical (NBS) analysis to explain brain structural network alterations in TSC patients with different intellectual disability, seizure, and Neurological Severity Score.

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