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Abstract #1547

Myelin Water Imaging in the Hybrid State

Andrew Mao1,2,3, Sebastian Flassbeck1,2, Cem Gultekin4, Xiaoxia Zhang1,2, and Jakob Asslaender1,2
1Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research, New York University School of Medicine, New York, NY, United States, 3Vilcek Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States, 4Courant Institute of Mathematical Sciences, New York University, New York, NY, United States

This work extends the recently introduced hybrid-state model to myelin water imaging. We numerically optimize a hybrid-state MR fingerprinting sequence for SNR efficiency and demonstrate in vivo the ability to quantify the myelin water fraction and T2 of axonal/extra-axonal water. Our preliminary results show myelin water fraction maps in agreement with literature and demonstrate the feasibility of simultaneous myelin water fraction, T1 and T2 quantification with high spatial resolution (1.2mm isotropic), full brain coverage with a 14 minute scan.

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