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Abstract #1539

Validity and repeatability of MRF in glioma and normal appearing contralateral brain tissue at 3T

Simran Kukran1,2, Joely Smith3,4, Luke Dixon1,3, Ben Statton5, Sarah Cardona3, Lillie Pakzad-Shahabi6,7, Matthew Williams6,8, Dow-Mu Koh2,9, Rebecca Quest3,4, Matthew Orton2, and Matthew Grech-Sollars1,3
1Department of Surgery and Cancer, Imperial College London, London, United Kingdom, 2Department of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 3Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 4Department of Bioengineering, Imperial College London, London, United Kingdom, 5Medical Research Council, London Institute of Medical Sciences, Imperial College London, London, United Kingdom, 6Computational Oncology group, Institute for Global Health Innovation, Imperial College London, London, United Kingdom, 7John Fulcher Neuro-oncology Laboratory, Department of Brain Sciences, Imperial College London, London, United Kingdom, 8Radiotherapy Department, Charing Cross Hospital, London, United Kingdom, 9Department of Radiology, Royal Marsden Hospital, London, United Kingdom

MR Fingerprinting (MRF) was found to give highly repeatable T1 and T2 measurements in glioma and normal appearing contralateral brain tissue. Validity was investigated via comparison to standard mapping techniques: variable flip angle for T1 and multi-echo spin echo for T2. Biases were found between MRF and standard relaxometry methods, as in previous healthy volunteer studies. Statistically significant strong and moderate correlations were found between the MRF and standard mapping methods for T1 and T2 respectively, indicating MRF is comparably sensitive to changes in T1 and T2 as established mapping techniques in both cancerous and normal appearing contralateral brain tissue.

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