Abstract #1527

Task-phase fMRI evidencing cognitive improvement post carotid angioplasty and stenting (CAS) – initial findings of a follow-up study

Betty Chinda^1,2, Simon Liang³, William Siu⁴, George Medvedev⁵, and Xiaowei Song^1,2

¹Department of Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, BC, Canada, ²Health Research and Innovation, Fraser Health Authority, Surrey, BC, Canada, ³Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Department of Radiology, Royal Columbian Hospital, New Westminster, BC, Canada, ⁵Department of Neurology, Royal Columbian Hospital, New Westminster, BC, Canada

This longitudinal task-phase fMRI study aims to provide direct evidence of possible effects of Carotid angioplasty and stenting (CAS) on cognition. The initial phase enrolled patients with severe carotid stenosis (≥70% stenosis) who had MRI scans pre-CAS and two-month post-CAS. At each scan, patients completed two fMRI sessions while performing a working memory task. Improved cerebral perfusion to areas supplied by carotid arteries following CAS was correlated with improved cognitive function in working memory performance along with increased fMRI activations in the re-perfused vascular territory especially in frontal and temporal lobes and reduced in the contralateral hemisphere.

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