We investigated habituation in migraine, by measuring repetition effects to emotional faces using BOLD-fMRI, during all phases of the migraine cycle. We first performed simulations to determine the sensitivity of the proposed fMRI paradigm and respective BOLD deconvolution approach to detect repetition effects, and then applied this to real data. Simulations showed that a commonly used deconvolution approach was able to correctly estimate repetition effects provided that response delays did not significantly deviate from default. When applied to real data, we found that controls exhibited the normal repetition suppression, but patients exhibited response maintenance or even potentiation.
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