Abstract #1490

Sensitivity-enhanced and Shading-reduced Chemical Exchange Saturation Transfer Imaging of the Abdomen using Parallel Transmission

Ruibin Liu¹, Zihua Qian², Zhe Wu³, Yi-Cheng Hsu⁴, Caixia Fu⁵, Yi Sun⁴, Dan Wu¹, and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China, ³Techna Institute, University Health Network, Toronto, ON, Canada, ⁴MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁵MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

CEST imaging benefits from longer saturation duration and a higher saturation duty cycle. Dielectric shading effects occur when the RF wavelength approaches the object size. Here, we proposed a parallel-transmission-based CEST (pTx-CEST) sequence to extend the maximum saturation duration at 100% duty-cycle and mitigate shading effects. The maximum saturation duration in pTx-CEST was lengthened to 2170, 3150, and 4130ms compared to 1050ms in non-pTx-CEST at TR of 3s, 4s, and 5s, respectively, leading to a significant sensitivity enhancement. Besides, the optimal amplitude ratio and phase difference between RF channels, manifesting circular or elliptical polarization, help reduce the dielectric shading effects.

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