Abstract #1475

Reproducible high-resolution T1Ρ maps of the brain in under seven minutes using compressed sensing

Gabriele Bonanno^1,2,3, Tom Hilbert^4,5,6, Patrick Leibig⁷, and Tobias Kober^4,5,6

¹Advanced Clinical Imaging Technology,Siemens Healthcare AG, Bern, Switzerland, ²Translational Imaging Center, sitem-insel AG, Bern, Switzerland, ³Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁶LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁷Siemens Healthcare GmbH, Erlangen, Germany

Relaxometry in the rotating frame can give unique insights into low frequency biological processes, and therefore may be a valuable quantitative MRI method for clinical research of neurodegenerative diseases. However, T_1ρ maps require long scan times for whole-brain coverage with high isotropic resolution. We present a T_1ρ mapping method based on an accelerated spiral-phyllotaxis 3D Cartesian gradient echo scan with compressed sensing reconstruction that allows for <7-min acquisition time and provides maps directly at the scanner to facilitate a fast workflow for clinical applications. Our method also demonstrated excellent repeatability and reproducibility.

This abstract and the presentation materials are available to members only; a login is required.

Join Here