Abstract #1470

An ASL and CrCEST combined protocol at 3T in the Study of Metabolic and Perfusion Changes Post Revascularization in Peripheral Arterial Disease

Helen Sporkin¹, Toral Patel², Christopher Schumann², Christopher Kramer^2,3, and Craig Meyer^1,3

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Cardiovascular Medicine, University of Virginia, Charlottesville, VA, United States, ³Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

Patients with peripheral arterial disease (PAD) have been shown to have a delayed phosphocreatine recovery due to chronic ischemia. Creatine chemical exchange saturation transfer (CrCEST) is an MRI technique that allows for creatine concentrations to be monitored at high spatial resolution. Combining ASL and CrCEST in the same protocol allows for spatial visualization of metabolism and perfusion. The goal of this study is to use this combination to assess changes after revascularization in patients undergoing both endovascular and surgical procedures and evaluate the recovery of both perfusion and metabolism in their muscle tissue.

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