Abstract #1468

Whole-brain amide CEST at 3T with a steady-state radial MRI acquisition

Ran Sui^1,2,3, Lin Chen^1,2, Yuguo Li^1,2, Jianpan Huang⁴, Kannie W.Y Chan^2,4, Xiang Xu⁵, Peter C.M.van Zijl^1,2, and Jiadi Xu^1,2

¹F.M. Kirby Research Center for Functional Brain Imagin, Kennedy Krieger Institute, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ⁵BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

We aim to develop an acquisition and processing pipeline for amideCEST mapping on human brain at 3T. This includes steady-state radial CEST (starCEST) using PROPELLOR-based sampling to acquire Z-spectra that are robust to brain motions and one multi-linear singular value decomposition (MLSVD) post-processing for enhancing the CEST SNR. Finally, the amideCEST peak was quantified using the polynomial and Lorentzian line-shape fitting (PLOF) approach.The amideCEST contrast extracted by the PLOF method trended towards a stronger gray matter (GM) signal (1.33% ± 0.34%) than white matter (WM) (0.92% ± 0.09%; p=0.06, n=4).

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