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Abstract #1465

Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open source sequence standard

Kai Herz1,2, Sebastian Mueller1, Maxim Zaitsev3, Linda Knutsson4,5, Jinyuan Zhou5, Phillip Zhe Sun6, Peter van Zijl5,7, Klaus Scheffler1,2, and Moritz Zaiss1,8
1Magnetic Resonance Center, MPI for Biological Cybernetics, Tuebingen, Germany, 2Biomedical Magnetic Resonance, University of Tuebingen, Tuebingen, Germany, 3Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 4Medical Radiation Physics, Lund University, Lund, Sweden, 5Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Yerkes Imaging Center, Emory University, Atlanta, GA, United States, 7F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 8Neuroradiology, Friedrich‐Alexander Universität Erlangen‐Nuernberg, Erlangen, Germany

The design of the preparation period is crucial for a CEST experiment, thus, a common, easy-to-use and vendor-independent file format to share exact preparation parameters is desirable. Here, we propose the use of Pulseq to define CEST parameters in an open source and human-readable file format. By providing a protocol database, a pulseq-compatible Bloch-McConnell simulation and a hybrid sequence using Pulseq for CEST preparation, we present a straightforward approach to standardize, share, simulate and measure different CEST preparation schemes, which are inherently completely defined.

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