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Abstract #1453

Open source Pulseq interpreter for CEST MRI on Bruker systems

Sebastian Mueller1, Kai Herz1, Klaus Scheffler1,2, and Moritz Zaiss1,3
1High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Department of Biomedical Magnetic Resonance, Eberhard Karls University Tuebingen, Tuebingen, Germany, 3Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany

CEST MRI becomes a frequently applied tool, however, a lot of method development is still done on pre-clinical scanners. Here we propose an approach that allows a fully automatic combination of existing MRI readouts for Bruker systems with open source pulseq-files for definition of CEST pre-saturation, without additional sequence programming. We believe that our work facilitates both basic research on CEST MRI and straightforward implementation of sophisticated, precisely defined CEST experiments on Bruker systems. Additionally, the use of Pulseq provides a universal, sharable standard to run the exact same pre-saturation in simulations and on clinical devises at a later stage.

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