We investigated the relationship between immune infiltration and imaging metrics derived from breast MRI in patients with triple negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NAC). Thirty-six patients with localized TNBC were imaged with diffusion-weighted and dynamic contrast-enhanced MRI prior to initiation of NAC. Baseline tumor infiltrating lymphocytes (TILs) and functional tumor volume were found to significantly differ between patients who achieved pathological complete response (pCR) compared to non-pCR patients. Baseline ADC showed a weak negative correlation with TIL counts.
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