Cortical Mapping and T1-Relaxometry using Motion Corrected MPnRAGE: Test-Retest Reliability with and without Motion Correction

A test-retest study of FreeSurfer cortical thickness, surface area, and volume, as well as cortical R1 relaxometry, was performed on pediatric subjects scanned without sedation using SNARE-MPnRAGE. Reliability was assessed with coefficients of variation (CoVs) and intraclass correlation coefficients (ICCs). When SNARE motion correction was used all parameters had statistically significant improvements and high reliability. For the mean (thickness/surface area/volume/R1) across the regions of FreeSurfer’s DK Atlas, the mean CoVs (% x100) were (1.2/1.6/1.9/0.9) and the mean ICCs were (0.88/0.96/0.94/0.83). When assessed on a per-vertex basis, the CoVs and ICCs for thickness/R1 had mean values of (2.9/1.9) and (0.82/0.68).