Abstract #1318

Distortion-Free Diffusion-Relaxometry Imaging with Self-navigated Cartesian-based Echo-Planar Time Resolved Acquisition (cEPTI)

Erpeng Dai¹, Philip K Lee^1,2, Zijing Dong^3,4, Fanrui Fu¹, Kawin Setsompop^1,2, and Jennifer A McNab¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States

Recently, there has been a growing interest in developing distortion-free EPI acquisitions for high-fidelity diffusion, relaxometry and/or functional MRI. Point spread function (PSF)-based techniques have been proposed for distortion-free diffusion imaging. Another technique, echo-planar time resolved imaging (EPTI), has been demonstrated for distortion-free relaxometry with an EPI readout. Additionally, a combination of PROPELLER and EPTI has been reported for motion-robust simultaneous diffusion and relaxometry imaging. In this study, we develop a self-navigated Cartesian-based EPTI (cEPTI) acquisition for distortion-free diffusion-relaxometry imaging. In vivo human brain data demonstrate that high-quality distortion-free diffusion and relaxometry images can be acquired with the proposed cEPTI.

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