Carbogen-based cerebrovascular reserve (CO2-CVR), derived from 90 normal subjects, was constructed for data-based approaches or analysis. Tissue, territorial and cortical specificities of CO2-CVR were evaluated by regions of interest (ROI) approaches. Global ratio of GM/WM CO2-CVR was about 1.57. Territorial and cortical specificities of CO2-CVR demonstrated (1) limited CO2-CVR in territories of posterior circulation which supported the pathophysiology of posterior reversible encephalopathy syndrome and (2) vital function in distal territories of anterior cerebral artery as verified by cortical parcellation with the highest of CO2-CVR at ventral portion of Brodmann area 23 (co-localized with posterior cingulate cortices of default mode network).
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