Abstract #1284

Impact of b-value on the estimation of white matter fiber orientation dependent R2*

Melanie Bauer^1,2, Celine Berger^1,2, Claudia Lenz^1,2, Eva Scheurer^1,2, and Christoph Birkl³

¹Institute of Forensic Medicine, Biomedical Engineering, University of Basel, Basel, Switzerland, ²Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland, ³Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria

To generate precise diffusion images in post mortem MRI, higher b-values are necessary than for in vivo MRI due to decreased diffusion. In this study, the influence of different b-values on the fiber orientation dependency of R₂* was assessed in 12 post mortem and 4 in vivo cases. Our results show that R₂* values are higher but their orientation dependency is lower post mortem than in vivo. However, the chosen b-values did not affect the estimation of the white matter fiber angle and, hence, the orientation dependency of R₂* for both post mortem in situ and in vivo MRI.

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