Abstract #1281

The relationship between Cerebrovascular Reactivity and baseline Cerebral Blood Flow: the effect of acquisition and analysis choices

Rachael C Stickland¹, Kristina M Zvolanek^1,2, Stefano Moia^3,4, Apoorva Ayyagari^1,2, César Caballero-Gaudes³, and Molly G Bright^1,2

¹Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ²Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States, ³Basque Center on Cognition, Brain and Language, Donostia, Spain, ⁴University of the Basque Country EHU/UPV, Donostia, Spain

Blood Oxygen Level Dependent (BOLD) signals can be modulated by the baseline vascular and metabolic state. Understanding how baseline vascular physiology relates to dynamic neurovascular processes will lead to more accurate interpretations of BOLD Cerebrovascular Reactivity (CVR) measurements. We investigated the relationship between baseline Cerebral Blood Flow (bCBF) and BOLD-CVR, generally reporting positive correlations. Optimizing for vascular delays, and modelling with simple breathing task data, can improve CVR correlations with bCBF. Future work should investigate individual differences and include larger samples.

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