A non-invasive method allowing the probing of the relative ω-3 fatty acid content in adipose tissue has the potential to reveal unknown metabolic patterns in physiology and pathology. In the current study, a model-based triglyceride mapping scheme is extended to enable the differentiation between ω-3 and non-ω-3 fatty acids by exploiting additional knowledge about the chemical shift properties. This extended scheme is combined with a chemical shift encoding imaging sequence and evaluated in a phantom validation experiment against gas chromatography–mass spectrometry. Furthermore, feasibility is demonstrated in both in vitro and in vivo settings.
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