A neuromelanin-sensitive imaging protocol based on a GRE sequence, sandwich-fsNM, is developed using multiple flow saturation pulses instead of MT pulses. The flow saturation pulses are located both superior and inferior to the imaging volume, like a sandwich, to avoid asymmetric MT across slices. The proposed protocol yields higher contrast between crus cerebri and substantia nigra and better visualizes locus coeruleus, compared to MT prepared GRE or TSE sequences.
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