Abstract #1233

Three-dimensional whole-brain simultaneous quantitative mapping of T1, T2, T2*, and susceptibility with MR Multitasking

Tianle Cao^1,2, Sen Ma¹, Nan Wang¹, Sara Gharabaghi³, Yibin Xie¹, Zhaoyang Fan^1,4,5, Elliot Hogg⁶, E. Mark Haacke ^3,7,8, Michele Tagliati⁶, Anthony G. Christodoulou^1,2, and Debiao Li^1,2

¹Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Magnetic Resonance Innovations, Inc., Bingham Farms, MI, United States, ⁴Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁵Department of Radiology, University of Southern California, Los Angeles, CA, United States, ⁶Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, United States, ⁷Department of Radiology, Wayne State University School of Medicine, Detroit, MI, United States, ⁸The MRI Institute for Biomedical Research, Bingham Farms, MI, United States

A new approach for simultaneous quantitative mapping of T1, T2, T2*, and susceptibility was developed. This technique employs hybrid T2 preparation/inversion pulse modules followed by fully flow-compensated multi-echo FLASH readouts. Our method reconstructs images with different T2 preparation times, echo times, and inversion times in the MR Multitasking framework and use them for parameter quantification. Results of both visual comparison and statistical analysis showed that our proposed method agreed well with reference methods while being more time efficient.

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