Thalamocortical dysrhythmia (TCD) has been implicated in the neuropsychiatric disorders in patients following mild traumatic brain injury (mTBI). We investigated the time-course diffusion tensor changes in the rodent brain up to 35 days using a controlled closed head injury model. Significant and persistent elevation of fractional anisotropy (FA) and reduced radial and mean diffusivities were found at the boundary of bilateral thalami where high shear stress was expected, suggesting that disinhibition of inhibitory circuits from the thalamic reticular nucleus (TRN) may play a role in TCD.
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