In this study, we demonstrate the application of deuterium MRS(I) for in vivo rat brain imaging. Administration of [2H7]glucose via the tail vein produced deuterated lactate and glx analogous to earlier reports, but here we show for the first time that HDO generated from metabolism can be imaged in the rodent brain. By using HDO evolution as a metric of glucose utilization, we introduce a biomarker of cerebral glycolysis and oxidative flux that is imaged with superior sensitivity and resolution.
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