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Abstract #1209

Changes in Correlation Between Brain Metabolites Due to Acute Stress in Mouse Hippocampus using Proton Magnetic Resonance Spectroscopy

Chang-Soo Yun1, Yoon Ho Hwang2, Min-Hee Lee3, Wooseung Kim2, Jehyeong Yeon1, Hyeon-Man Baek4, Dong Youn Kim2, and Bong Soo Han1
1Radiation Convergence Engineering, Yonsei University, Wonju-si, Gangwon-do, Korea, Republic of, 2Biomedical Engineering, Yonsei University, Wonju-si, Gangwon-do, Korea, Republic of, 3Institute of Human Genomic Study, Korea University, Ansan-si, Gyeonggi-do, Korea, Republic of, 4Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon-si, Korea, Republic of

We investigated the changes in correlation between mouse brain metabolites due to acute restraint stress using magnetic resonance spectroscopy (MRS). Acquired time series MRS data of the control and acute stress groups were quantified using LCModel. Correlation coefficients between metabolites were calculated from time series metabolite concentration and metabolite pairs with statistically significant correlations were selected using one-sample Sign Test ( p < 0.05 ). We found that Gln-GSH, NAA-Glu and NAA-GSH showed new significant correlations in the acute stress group. Our findings suggest that correlation can be a useful measurement in assessing the effects of stress.

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