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Abstract #1204

Whole-Brain T1 and T2 Mapping in Mouse by 3D Magnetic Resonance Fingerprinting

Yuran Zhu1, Yuning Gu1, Kihwan Kim1, Charlie Androjna2, Chris A. Flask1,3,4,5, Yong Chen3,6, and Xin Yu1,3,7
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 3Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 4Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States, 5Cancer Imaging Program, Case Western Reserve University, Cleveland, OH, United States, 6Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 7Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

We present a 3D MR fingerprinting (MRF) sequence for simultaneous T1 and T2 mapping in mouse. Data acquisition and reconstruction covered a field of view (FOV) of 30 × 30 × 9 mm3 with a matrix size of 128 x 128 x 9, yielding a spatial resolution of 0.23 × 0.23 × 1 mm3. Retrospective undersampling analysis was performed on fully-sampled phantom and mouse data to examine the undersampling capacity of the proposed sequence, demonstrating that the method supports up to 16-fold in-plane undersampling with a 3-fold through-plane undersampling.

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