Abstract #1180

Improved Sampling for Distortionless Diffusion Weighted 2D Cartesian Multi-Shot Fast Spin Echo

Philip Kenneth Lee^1,2, Yuxin Hu^1,2, Catherine Judith Moran², Bruce Lewis Daniel², and Brian Andrew Hargreaves^1,2,3

¹Electrical Engineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States, ³Biomedical Engineering, Stanford University, Stanford, CA, United States

In diffusion weighted imaging, multi-shot Echo Planar Imaging (EPI) is preferred over single-shot EPI due to reduced geometric distortion. Recent work has shown that low-rank reconstructions can correct ghosts from shot-to-shot phase without explicitly acquiring a phase navigator. These works have been limited to EPI sampling trajectories with uniform ky sampling. 2D Cartesian Fast Spin Echo (FSE) is a distortionless alternative to multi-shot EPI that has greater freedom in k-space traversal and reduced chemical shift artifacts. Using FSE, we demonstrate in simulation and in vivo that an intelligent choice of sampling pattern greatly enhances image quality in multi-shot diffusion imaging.

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