Abstract #1128

Evaluation of Lactating Breasts Using Diffusion Tensor Magnetic Resonance Imaging: A Feasibility Study.

Anabel M Scaranelo¹, Hadassa Degani², Dov Grobgeld³, Vivianne Freitas¹, Shelley Westergard⁴, Christine Elser⁵, and Edna Furman-Haran³

¹Medical Imaging, University of Toronto, Toronto, ON, Canada, ²DDE MRI Solutions Ltd., Tel Aviv, Israel, ³Weizmann Institute of Science, Rehovot, Israel, ⁴Princess Margaret Cancer Center, Toronto, ON, Canada, ⁵University of Toronto, Toronto, ON, Canada

The performance of breast DTI in the diagnosis of breast cancer in high-risk lactating patients as compared to DCE imaging was prospectively assessed. The study included 38 patients of which six were diagnosed with breast cancer. All six cancers were detected by DTI and showed significantly lower diffusion coefficients and lower anisotropy in comparison to contralateral normal breast tissue. Sensitivity, specificity and accuracy were respectively, 100%, 93.2%, 93.8% for DTI and 66.7%, 83.8% and 82.5% for DCE. The results showed the potential of breast DTI as an aid in the diagnostic workup of high-risk women during the lactation period.

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