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Abstract #1078

The relative cerebral blood volume in normal-appearing white and grey matter remains almost constant following radio(chemo)therapy

Katharina Witzmann1,2, Felix Raschke1,2, Tim Wesemann3, Mechthild Krause1,2,4,5,6, Jennifer Linn3, and Esther G.C. Troost1,2,4,5,6
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany, 2OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 3Institute of Neuroradiology, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität Dresden, Dresden, Germany, 4Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, 5National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and; Helmholtz Association / Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany, 6German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany

In adjuvant radio(chemo)therapy of glioma patients, irradiation of tumor-surrounding normal tissue is unavoidable, potentially leading to long-term side-effects. We analyzed radiation-induced perfusion changes measured as relative cerebral blood volume (rCBV) in supraventricular grey and white matter regions of 17 glioma patients before and 3, 6 and 9 months after radiotherapy. After treatment, perfusion remained constant in the entire regions and after dose-separation, except for a statistically significant rCBV decrease in low-dose white matter volumes 6 months after the end of radiotherapy (p=0.008) and a trend towards increasing white and grey matter perfusion in high-dose volumes at 9 months (p<0.1).

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