Relative cerebral blood volume (rCBV) maps are adversely impacted by contrast agent leakage effects when acquired using gadolinium-based contrast agents, and these effects can be corrected using standard leakage correction methods. In a cohort of high-grade glioma patients, we compared leakage-corrected rCBV maps acquired using gadolinium-based contrast agents to rCBV acquired using an intravascular iron-oxide-based contrast agent. The rCBV maps from both contrast agents were similar, with high voxel-wise agreement, suggesting that leakage effects are appropriately removed from rCBV maps using standard leakage correction methods.
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