Myalgic Encephalomyelitis (ME)/Chronic fatigue syndrome (CFS) patients suffer from a variety of physical and neurological complaints indicating the central nervous system plays a role in ME/CFS pathophysiology. Structural and functional magnetic resonance imaging have been used to identify the pathomechanism of ME/CFS However, changes in tissue microstructure to understand the pathomechanism of ME/CFS using diffusion tensor imaging (DTI) have not been fully investigated. Our DTI study showed abnormality of the brain stem in ME/CFS patients relative to healthy controls.
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