In this study, we investigated the spatial extent and location of white-matter (WM) disorganization due to repeated head impacts (RHI) by estimating single-tensor (ST) diffusion MRI (dMRI)-measures along with free-water (FW)-corrected ST measures, diffusion kurtosis imaging (DKI), and Neurite Orientation Dispersion and Density Imaging (NODDI) measures, along with understanding the correlation of such voxelwise measures with exposure to fighting and neuropsychological scores. Overall, our findings suggest that WM disorganization is prevalent in thalamocortical and corpus-callosum fibers due to RHI, although, the spatial extent and location of these differences are heavily dependent on the dMRI-models utilized in the study.
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