Obesity is an ongoing epidemic that is associated with cognitive dysfunction and is a prominent precursor to a variety of neurogenerative diseases. Bariatric surgery is an effective and long-term weight loss strategy that can improve neurocognitive function. However, the mechanisms that drive these improvements are unknown. In this study, magnetic resonance imaging (MRI) is utilized to assess changes in cerebral metabolic rate of oxygen (CMRO2) levels in bariatric surgery candidates before and after their surgery. These values are compared with normal healthy weight controls of a similar age and reassessed after 2 weeks and 14 weeks.
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