Abstract #1032

Anisotropic Mechanical Properties of White Matter Tracts Estimated with Multi-Excitation MRE and TI-NLI

Daniel R. Smith¹, Diego A. Caban-Rivera¹, Matthew D. J. McGarry², L. Tyler Williams¹, Grace McIlvain¹, Charlotte Guertler³, Ruth J. Okamoto³, Damian Sowinski², Elijah Van Houten⁴, Phil V. Bayly³, Keith D. Paulsen², and Curtis L. Johnson¹

¹Biomedical Engineering, University of Delaware, Newark, DE, United States, ²Thayer School of Engineering, Dartmouth College, Hanover, NH, United States, ³Mechanical Engineering and Materials Science, Washington University in St. Lous, St. Louis, MO, United States, ⁴Mechanical Engineering, Universite de Sherbrooke, Sherbrooke, QC, Canada

In this study, we used multi-excitation MR elastography (MRE) in conjunction with transversely isotropic NLI (TI-NLI) to estimate the anisotropic viscoelastic parameters of the human brain. We collected data on ten subjects and took averages of the parameters within individual regions of the brain. Through comparison of regions of interest, we found significant differences between the parameter estimate of gray matter and white matter and between individual white matter tracts. The results of this study indicate that multi-excitation MRE and TI-NLI can generate consistent anisotropic parameter estimates for WM that capture innate differences in individual tract structure.

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