Radiation therapy (RT) is used by more than 50% of all cancer patients, where the risk of RT-induced cardiotoxicity reaches 33%. In this study, we investigate the role of cardiac contractility by MRI to differentiate the response of two different rat models to RT. The results showed the value of myocardial strain for early detection of RT-induced cardiotoxicity and exploring the effect of genetic profile and duration post-RT on cardiotoxicity. In conclusion, MRI strain imaging allows for determining spatial distribution and temporal progression of myocardial contractility post-RT, which would allow for determining the effect of genetic profile on cardiotoxicity development.
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