Banu Sacli-Bilmez1, Ayca Ersen Danyeli2,3, Murat Şakir Ekşi4, Kübra Tan5, Ozge Can6, Cengiz Yakicier7, M.Necmettin Pamir3,4, Alp Dincer3,8, Koray Özduman3,4, and Esin Ozturk-Isik1
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Department of Medical Pathology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 3Center for Neuroradiological Applications and Reseach, Acıbadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 4Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 5Health Institutes of Turkey, Istanbul, Turkey, 6Department of Medical Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 7Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 8Department of Radiology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Meningiomas are a heterogeneous group of tumors that arise at the
pachymeninges and tend to invade surrounding bone and rarely the brain. In this
work, we studied the single-voxel 1H-MRS correlates of aggressive
biology (measured by WHO grade), peritumoral edema, brain invasion, bone
invasion, skull base location in meningiomas. Higher Glyc and Ins+Glyc levels were observed in
aggressive (WHO grade II or III) meningiomas. Higher Glu, GPC, and Glx levels
were observed in hyperostotic tumors. The classification accuracies were 81.28%
for tumor grade, 73.18% for hyperostosis detection, and 76.88% for skull base
localization of meningiomas.
