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Abstract #0952

The Effect of Cramer-Rao Lower Bound Thresholds on Classification of IDH and TERTp Mutation Status in Gliomas using 1H-MRS

Abdullah Bas1, Banu Sacli-Bilmez1, Ayca Ersen Danyeli2,3, Cengiz Yakicier3,4, M.Necmettin Pamir3,5, Koray Ozduman3,5, Alp Dincer3,6, and Esin Ozturk-Isik1,3
1Institute of Biomedical Engineering, Bogazici University, İstanbul, Turkey, 2Department of Medical Pathology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 3Center for Neuroradiological Applications and Reseach, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 4Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 5Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 6Department of Radiology, Acıbadem Mehmet Ali Aydinlar University, Istanbul, Turkey

Cramer-Rao lower bound (CRLB) is commonly employed as an exclusion criterion for bad quality MR spectra. This study aims to investigate the CRLB differences of the metabolites between isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase promoter (TERTp) mutational subgroups in gliomas, and to assess the effects of CRLB threshold on their classifications. GPC, PCh, 2HG, and Ins were more reliably detected in IDH-mutant gliomas. Ins had higher CRLB values in TERTp-mutant than TERTp-wildtype gliomas. Different CRLB thresholds followed by zero-imputing had a small impact on the classification accuracies, but affected the choice of best features and classification algorithms.

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