Combination of evofosfamide and chemotherapy suppress tumor growth than using these drugs alone. The purpose of this study is to detect physiologic changes in tumor-bearing mouse model in response to combination of evofosfamide and gemcitabine (GEM) using multi-modal imaging methods including DCE-MRI, blood volume imaging, and EPRI. Significantly increased perfusion, maintained blood volume, and maintained hypoxic fraction < 10 mmHg were observed after treatment with combination of evofosfamide and GEM. The results validate the utility of these imaging methods to non-invasively monitor changes in the tumor microenvironment after treatment.
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