Rapid high-resolution echo-planar-imaging (EPI) with improved image quality could conceivably be utilized as a high-speed alternative to conventional T2-weighted fast-spin-echo imaging (T2-FSE). A variant of multi-shot EPI, DIADEM (distortion-free imaging: a double encoding method), was recently described (5) and shown to yield high quality, high resolution images free of spatial distortion. In this work, a T2-weighted DIADEM pulse sequence was optimized with self-calibrated, tilted-CAIPI reconstruction scheme and then comparatively evaluated to T2-FSE images of the brain in 24 human subjects by two neuroradiologists.
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