We address the challenges of QSM in regions outside of the brain which contain disconnected structures - leading to difficulty in masking - and significant amounts of fat with chemical shift and relaxation differences relative to water - leading to errors in susceptibility estimates. We propose a mask generation approach based on signal phase and show that the errors in susceptibility estimates can be eliminated using simultaneous fat-water imaging with SMURF. Using multi-echo acquisition and inverse-variance-weighted echo combination, we generate high CNR, chemical shift and relaxation effects-free susceptibility maps of the head-and-neck at 7T.
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