Abstract #0759

Prediction of prognosis after definitive radiotherapy for uterine cervical cancer using changes of ADC histogram during the clinical course

Akiyo Takada¹, Hajime Yokota², Miho Watanabe Nemoto², Takuro Horikoshi¹, Koji Matsumoto¹, Yuji Habu³, Hirokazu Usui³, Katsuhiro Nasu¹, Makio Shozu³, and Takashi Uno²

¹Radiology, Department of Radiology, Chiba University Hospital, Chiba, Japan, ²Radiology, Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan, ³Obstetrics and gynecology, Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

To realize precision medicine for cervical cancer, it is essential to predict the prognosis. We focused on changes in ADC histogram during the clinical course. Sixty-eight patients were included and they underwent MRI evaluation 4 times during the clinical course. Imaging features were extracted from the ADC histogram in the whole tumor VOI and their change rates were calculated. The change rates of kurtosis between the first and third, and between the first and second imaging could predict recurrence with high AUCs (0.90 and 0.83). By predicting the prognosis early during clinical course, a more personalized treatment can be provided.

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