Huntington’s Disease (HD) is a neurodegenerative disorder with severe cognitive and motor impairment caused by abnormal cytosine-adenine-guanine (CAG) repeat expansion within the HTT gene. The goal of this study was to explore differences in iron deposition measured by quantitative susceptibility mapping (QSM) and volume of basal ganglia structures between healthy controls and patients with pre-manifest HD or early manifest HD and correlate them with clinical variables. The caudate and putamen exhibited atrophy that increased with disease severity, CAP score, and impaired motor function. Iron deposition increased with the onset of symptoms, CAP scores, and cognitive decline.
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