We compared three myelin-sensitive MRI metrics (inhomogeneous magnetization transfer ratio (ihMTR), magnetization transfer ratio (MTR) and gradient and spin echo-derived myelin water fraction (MWF)) in 15 white matter regions of interest from 14 healthy adults at 3T. Reproducibility of ihMTR was also investigated. We found a moderately strong correlation between MWF and ihMTR but only a very weak correlation between MWF and MTR. Myelination rankings were similar for ihMTR and MWF but had no relation to MTR. Finally, we established an average ihMTR scan-rescan variability of 8.2% of the mean in each ROI.
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