Abstract #0685

Myofiber strain in healthy humans using cDTI and Cine DENSE MRI

Kevin Moulin^1,2,3, Pierre Croisille^4,5, Magalie Viallon^4,5, Ilya A Verzhbinsky⁶, Luigi E Perotti⁷, and Daniel B Ennis^1,2,3

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, ³Cardiovascular Institute, Stanford University, Stanford, CA, United States, ⁴University of Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM U1206, CREATIS, F-42023, Saint-Etienne, France, ⁵Department of Radiology, University Hospital Saint-Etienne, Saint-Etienne, France, ⁶Medical Scientist Training Program, University of California - San Diego, La Jolla, CA, United States, ⁷Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL, United States

Despite the importance of myofiber strain (E_ff) to overall heart function, it has remained very difficult to measure E_ff in vivo owing to the challenges of measuring both microstructural and functional cardiac data. We propose a new method that integrates cDTI and a volume of short- and long-axis DENSE slices with 2D displacement encoding to enable the measurement of in vivo Eff in humans. The accuracy of the approach for measuring Eff was evaluated in silico. Finally, in vivo E_ff values were measured and reported for thirty (N=30) healthy volunteers for which an average E_ff=-0.14 was found.

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