Abstract #0681

Extension of a Diagnostic Model for Pulmonary Hypertension with Hyperpolarized 129Xe Magnetic Resonance Imaging and Spectroscopy

Elianna Ada Bier¹, Fawaz Alenezi², Junlan Lu³, Joseph G Mammarappallil⁴, Bastiaan Driehuys⁴, and Sudarshan Rajagopal²

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Division of Cardiology, Department of Medicine, Duke Univeristy, Durham, NC, United States, ³Medical Physics Graduate Program, Duke University, Durham, NC, United States, ⁴Radiology, Duke University, Durham, NC, United States

¹²⁹Xe dynamic spectroscopy combined with ¹²⁹Xe gas exchange MRI can detect both pre- and postcapillary pulmonary hypertension (PH). However, reliance on whole lung spectroscopy limits this technique’s ability to detect spatially heterogeneous impacts of PH. For example, the algorithm cannot identify combined pre- and postcapillary PH (CpcPH) and does not currently account for out-of-proportion PH in patients with parenchymal disease. Here we use the recently introduced method of imaging signal oscillations from ¹²⁹Xe in red blood cells to gain additional insights into 26 subjects who have also undergone right heart catheterization to determine PH status within 2 months of imaging.

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