Abstract #0583

Decreased muscular perfusion in dermatomyositis: initial results detected by Inflow-based vascular-space-occupancy MR imaging

Yuankui Wu¹, Xiaomin Liu¹, Jun Hua^2,3, Xiaodan Li¹, Haimei Cao¹, Yingjie Mei⁴, and Yikai Xu¹

¹Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Philips healthcare, Guangzhou, China

Dermatomyositis (DM) is a chronic autoimmune microangiopathy. Accurate quantification of muscular microcirculation can assist in early diagnosis and improve clinical outcomes. Inflow-based vascular-space-occupancy (iVASO) is a novel perfusion technique without the need for exogenous contrast agents. This study aimed to determine the potential diagnostic value of iVASO-MRI for patients with DM. The results showed decreased arteriolar muscular blood volume (MBVa) in DM patients, which worsens with the progression of disease, and the diminished MBVa in morphologically-normal appearing muscles. This suggests that iVASO-derived MBVa has the potential to be used as a biomarker for early diagnosis of DM.

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