The stomach-brain interaction is critical for regulating gastric function. Prior studies suggest that the brain maintains a slow rhythm coupled to the gastric slow wave – a rhythmic activity that paces the stomach. Here, we find a brain network encodes the frequency and power fluctuations of gastric rhythms in the resting state. Rhythmic activity of the stomach primarily engages the NTS-insula-somatosensory network. Dysrhythmic activities, such as bradygastria and tachygastria engage additional regions in the anterior cingulate cortex, prelimbic cortex, and infralimbic cortex. The alternation of dysrhythmic and pace-making activity in the stomach causes activity fluctuations across a central gastric network.
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