Abstract #0553

Fast and repeatable multi-parametric mapping using 3D Echo-Planar Time-resolved Imaging (3D-EPTI)

Fuyixue Wang^1,2, Zijing Dong^1,3, Timothy G. Reese¹, Lawrence L. Wald^1,2, and Kawin Setsompop^4,5

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ³Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, ⁴Department of Radiology, Stanford University, Stanford, CA, United States, ⁵Department of Electrical Engineering, Stanford University, Stanford, CA, United States

3D-EPTI is a recent multi-parametric mapping technique capable of rapid T1,T2,and T2* quantification. In this work, we characterize the repeatability of two optimized 3D-EPTI whole-brain protocols at 1-mm and 0.7-mm isotropic resolutions (3- and 9-minutes), suitable for a range of clinical and neuroscientific applications. Scan-rescan across 5 subjects shows low intra- and inter-subject variabilities in the derived quantitative-metrics across 165 brain-regions using automatic FreeSurfer segmentation. High-repeatability of quantitative measures across cortical depths was demonstrated using the 0.7-mm protocol, indicating its potential for robust-and-repeatable cortical myeloarchitecture investigation. Lastly, synthetic 3D-EPTI images were demonstrated to be in high-agreement with clinical contrast-weighted images.

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