Hyposmia is prevalent in Parkinson’s disease (PD) and the central olfactory system is highly affected by PD pathology. Despite the considerable progresses in understanding the pathophysiology of the disease, the mechanism causing hyposmia in PD is still unclear. Given that there is early PD-related neurodegeneration in anterior olfactory nucleus, which is a part of the primary olfactory cortex, we tested the hypothesis that there are PD-related dysfunctions in the central olfactory functional network at the early stage of disease.
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