Abstract #0498

On the variability of single-point MPF mapping in the human brain using different Variable Flip Angle T1 mapping protocols

Lucas Soustelle^1,2, Thomas Troalen³, Andreea Hertanu^1,2, Maxime Guye^1,2, Jean-Philippe Ranjeva^1,2, Guillaume Duhamel^1,2, and Olivier M. Girard^1,2

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Siemens Healthcare SAS, Saint-Denis, France

Fast macromolecular proton fraction (MPF) mapping based on single-point (SP) quantitative MT method has shown great promises for the evaluation of myelin-related studies while allowing for acceptable scan times. The SP method requires a T₁ map, which is inherently biased by magnetization transfer effects. In this work, we investigate the effect of T₁ maps derived from different Variable Flip Angle (VFA) protocols on the computed MPF maps. It is shown that VFA-T₁ is highly variable because of MT effects, hence biasing SP-MPF maps values. The SP-MPF methodology should therefore consider MT effects in VFA-T₁ estimation, especially for cross-vendor applications.

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