Multi-shot 3D EPI is one of the most popular 3D imaging techniques for fMRI, which can provide higher SNR than 2D single-shot EPI. However, the vulnerability to inter-shot signal variations arising from physiological fluctuations, like respiration-related phase variations, has limited the tSNR benefits of 3D multi-shot acquisitions. To improve the temporal stability of 3D multi-shot EPI for fMRI at 7T, we investigated both the optimization of sampling trajectories which show varying vulnerabilities to the inter-shot inconsistencies, and the use of a low-rank annihilating filter constrained reconstruction which can reduce unwanted temporal variance induced by the inter-shot phase inconsistencies.
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