Multi-shot EPI enables high-resolution diffusion-weighted imaging with reduced geometric distortions. However, fat is often a confounding factor in EPI, especially in regions with severe B0 inhomogeneities. For the proposed method, data is acquired using TE-shifted interleaved EPI and 2D-navigators to sense the motion-induced shot phases. The reconstruction includes a multi-peak fat model and corrects for the fat frequency-specific chemical shift displacements in phase-encoding direction by a time-efficient image-space formulation. In-vivo results show that the proposed algorithm provides improved water/fat separation compared with the conventional technique and fat-suppressed acquisition.
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